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The CF Foundation and ECFS convened a 19-member committee of adult and pediatric experts in CF and NTM-related lung disease. The CF Foundation and ECFS created these consensus guidelines to help standardize the approach to NTM-PD.
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Other challenges exist in knowing how best to identify NTM, how to initiate treatment, and how NTM-PD affects lung transplantation consideration. NTM-PD is defined by microbiological, clinical, and radiographic features although it is clear that NTM can reside in the lungs of individuals with CF without causing progressive disease, making decisions on when to initiate treatment is challenging. The most commonly isolated organism is Mycobacterium avium complex comprising 72 percent of NTM positive cultures, followed by M. Nontuberculous mycobacteria are increasingly being isolated from the sputum of individuals with CF with estimates of prevalence increasing from 1.3 percent in 1984 to 12 percent in 2012. This summary highlights a comprehensive list of questions associated with screening, microbiology, diagnosis, treatment, and issues regarding transplantation. Cystic Fibrosis Foundation and the European Cystic Fibrosis Society (ECFS) convened a committee of experts to address the specific issues surrounding NTM pulmonary disease (NTM-PD) in individuals with CF. To better provide guidance for this challenging disease, the U.S. NTM lung disease in CF is emerging as a significant threat to these individuals, although there is limited data on diagnosis and treatment. Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause chronic pulmonary infection, particularly in individuals with pre-existing lung disease, such as cystic fibrosis. Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of nontuberculous mycobacteria in individuals with cystic fibrosis.
Cystic Fibrosis Foundation and European Cystic Fibrosis Society.
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